Oxidative stress is an important pathomechanism found in numerous ocular degenerative
diseases. To provide a better understanding of the mechanism and treatment of …

Lutein is a xanthophyll carotenoid obtained from various foods, such as dark green leafy
vegetables and egg yolk. Lutein has antioxidant activity and scavenges reactive oxygen …

The human lens is comprised largely of crystallin proteins assembled into a highly ordered,
interactive macro-structure essential for lens transparency and refractive index. Any …

Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …

The impact of proteins and peptides on the treatment of various conditions including ocular
diseases over the past few decades has been advanced by substantial breakthroughs in …

The crystalline lens plays an important role in the refractive vision of vertebrates by
facilitating variable fine focusing of light onto the retina. Loss of lens transparency, or …

Cataract, the clinical correlate of opacity or light scattering in the eye lens, is usually caused
by the presence of high-molecular-weight (HMW) protein aggregates or disruption of the …

Cataracts reduce vision in 50% of individuals over 70 years of age and are a common form
of blindness worldwide. Cataracts are caused when damage to the major lens crystallin …

The recent years have witnessed a rise in the number of intrinsically disordered proteins
(IDPs), also known as hybrid proteins, which possess both structured domains and …

Cataract is the leading cause of reversible blindness and visual impairment globally.
Blindness from cataract is more common in populations with low socioeconomic status and …