In many patients who suffer from epilepsies, recurrent epileptic seizures do not start at birth
but develop later in life. This holds particularly true for epilepsies with a focal seizure origin …

Acquired epilepsies can arise as a consequence of brain injury and result in unprovoked
seizures that emerge after a latent period of epileptogenesis. These epilepsies pose a major …

T-type, low-voltage activated, calcium channels, now designated Cav3 channels, are
involved in a wide variety of physiological functions, especially in nervous systems. Their …

Objective Inflammation of brain structures, in particular the hippocampal formation, can
induce neuronal degeneration and be associated with increased excitability manifesting as …

Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …

Highlights•Metal dyshomeostasis is implicated in cancer and neurodegenerative
diseases.•Chelators and ionophores remove or redistribute metals with therapeutic …

Evidence from both preclinical and clinical studies suggest the importance of zinc
homeostasis in seizures/epilepsy. Undoubtedly, zinc, via modulation of a variety of targets, is …

Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe
seizures, progressive memory disturbance, and other behavioral and cognitive changes …

Objective Limbic encephalitis (LE) comprises a spectrum of inflammatory changes in
affected brain structures including the presence of autoantibodies and lymphoid cells …

Transient brain insults including status epilepticus (SE) can initiate a process termed
'epileptogenesis' that results in chronic temporal lobe epilepsy. As a consequence, the entire …