Inflammatory bowel diseases are characterised by inflammation that compromises the
integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has …

Claudins are major integral membrane proteins of tight junctions. Altered expression of
several claudin proteins, in particular claudin-1,-3,-4 and-7, has been linked to the …

The mechanisms that control intracellular adhesion are central to the process of invasion
and metastasis. Claudin-3 (CLDN3) and claudin-4 (CLDN4) are major structural molecules …

The extent of tight junction (TJ) formation is one of many factors that regulate motility,
invasion, and metastasis. Claudins are required for the formation and maintenance of TJs …

The deregulation of claudin-3 has been reported to correlate with the invasion and
metastasis of various cancers, but little is known about its expression level and the …

Simple Summary Recent evidence has emerged highlighting the role of claudins in the
development of cancers of gastrointestinal organs. Accordingly, studies have further …

Background Tight junction proteins in the cell organize paracellular permeability and they
play a critical role in apical cell-to-cell adhesion and epithelial polarity. Claudins are major …

Background Cancer cells are characterized by chromosomal instability (CIN) and it is
thought that errors in pathways involved in faithful chromosome segregation play a pivotal …

The altered expressions of claudin proteins have been reported during the tumorigenesis of
colorectal cancer. However, the molecular mechanisms that regulate these events in this …

Claudins are a family of tight junction proteins regulating paracellular permeability and cell
polarity with different patterns of expression in benign and malignant human tissues. There …