Antisense oligonucleotides are synthetic single stranded strings of nucleic acids that bind to
RNA and thereby alter or reduce expression of the target RNA. They can not only reduce …

Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

Over 50% of all human cancers lose p53 function. To evaluate the role of aggregation in
cancer, we asked whether wild-type (WT) p53 and the hot-spot mutant R248Q could …

p53 is a master regulatory protein that participates in cellular processes such as apoptosis,
DNA repair, and cell cycle control. p53 functions as a homotetrameric tumor suppressor, and …

Lowering of prion protein (PrP) expression in the brain is a genetically validated therapeutic
hypothesis in prion disease. We recently showed that antisense oligonucleotide (ASO) …

Antiviral polymers are a well-studied class of broad spectrum viral attachment/entry
inhibitors whose activity increases with polymer length and with increased amphipathic …

Prion disease is a fatal, incurable neurodegenerative disease of humans and other
mammals caused by conversion of cellular prion protein (PrP C) into a self-propagating …

Prion diseases are transmissible, invariably fatal, neurodegenerative diseases which
include Creutzfeldt–Jakob disease (CJD) in humans and bovine spongiform …

Prions, the infectious agents of transmissible spongiform encephalopathies (TSEs), have
defied full characterization for decades. The dogma has been that prions lack nucleic acids …

Most of the cell's chemical reactions and structural components are facilitated by proteins.
But proteins are highly dynamic molecules, where numerous modifications or changes in the …