Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry

T Cajka, O Fiehn - TrAC Trends in Analytical Chemistry, 2014 - Elsevier
Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics has undergone
dramatic developments over the past decade. This review focuses on state of the art in LC …

Current approaches and challenges for the metabolite profiling of complex natural extracts

JL Wolfender, G Marti, A Thomas, S Bertrand - Journal of Chromatography …, 2015 - Elsevier
Metabolite profiling is critical in many aspects of the life sciences, particularly natural product
research. Obtaining precise information on the chemical composition of complex natural …

LipidBlast in silico tandem mass spectrometry database for lipid identification

T Kind, KH Liu, DY Lee, B DeFelice, JK Meissen… - Nature …, 2013 - nature.com
Current tandem mass spectral libraries for lipid annotations in metabolomics are limited in
size and diversity. We provide a freely available computer-generated tandem mass spectral …

Nutrimetabolomics: an integrative action for metabolomic analyses in human nutritional studies

MM Ulaszewska, CH Weinert… - Molecular nutrition & …, 2019 - Wiley Online Library
The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …

Novel advances in shotgun lipidomics for biology and medicine

M Wang, C Wang, RH Han, X Han - Progress in lipid research, 2016 - Elsevier
The field of lipidomics, as coined in 2003, has made profound advances and been rapidly
expanded. The mass spectrometry-based strategies of this analytical methodology-oriented …

New advances in separation science for metabolomics: resolving chemical diversity in a post-genomic era

NL Kuehnbaum, P Britz-McKibbin - Chemical reviews, 2013 - ACS Publications
Metabolomics offers a revolutionary framework for phenotyping individuals at a molecular
level that is needed for new breakthroughs in cell biology and personalized medicine. 1− 3 …

High-throughput and comprehensive lipidomic analysis using ultrahigh-performance supercritical fluid chromatography–mass spectrometry

M Lísa, M Holčapek - Analytical chemistry, 2015 - ACS Publications
New analytical approach for high-throughput and comprehensive lipidomic analysis of
biological samples using ultrahigh-performance supercritical fluid chromatography …

MPLEx: a robust and universal protocol for single-sample integrative proteomic, metabolomic, and lipidomic analyses

ES Nakayasu, CD Nicora, AC Sims… - …, 2016 - Am Soc Microbiol
Integrative multi-omics analyses can empower more effective investigation and complete
understanding of complex biological systems. Despite recent advances in a range of omics …

Analytical methods in lipidomics and their applications

M Li, L Yang, Y Bai, H Liu - Analytical chemistry, 2014 - ACS Publications
As a branch of metabolomics, lipidomics is aimed at full analysis of lipid species and their
biological roles with respect to health and diseases and has attracted increasing attention of …

Increasing lipidomic coverage by selecting optimal mobile-phase modifiers in LC–MS of blood plasma

T Cajka, O Fiehn - Metabolomics, 2016 - Springer
Reversed-phase ultrahigh-performance liquid chromatography–mass spectrometry (UHPLC–
MS) is the method of choice for lipidomic profiling of blood plasma. For comprehensive …