Monofluorination of organic compounds: 10 years of innovation

PA Champagne, J Desroches, JD Hamel… - Chemical …, 2015 - ACS Publications
Taking into account the vast arrays of fluorinated motifs known, 11 this review will be limited
to the monofluorination of organic compounds, ie, synthetic methods allowing the …

Organofluorine chemistry: Promising growth areas and challenges

LV Politanskaya, GA Selivanova… - Russian Chemical …, 2019 - iopscience.iop.org
Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

Reagents for selective fluoromethylation: A challenge in organofluorine chemistry

M Reichel, K Karaghiosoff - Angewandte Chemie International …, 2020 - Wiley Online Library
The introduction of a monofluoromethyl moiety has undoubtedly become a very important
area of research in recent years. Owing to the beneficial properties of organofluorine …

Synthesis of monofluoroalkenes: a leap forward

M Drouin, JD Hamel, JF Paquin - Synthesis, 2018 - thieme-connect.com
Monofluoroalkenes have found wide application in organic chemistry, medicinal chemistry,
and materials science. This review summarizes the most recent advances made regarding …

gem‐Heteroatom‐Substituted Fluoroalkenes as Mimics of Amide Derivatives or Phosphates: A Comprehensive Review

S Morand, P Jubault, JP Bouillon… - … A European Journal, 2021 - Wiley Online Library
Abstract gem‐Heteroatom‐substituted fluoroalkenes have received little attention despite
their great potential in medicinal chemistry or in fine chemistry. Indeed, due to the electronic …

Recent progress in the Horner-Wadsworth-Emmons reaction

JA Bisceglia, LR Orelli - Current Organic Chemistry, 2015 - ingentaconnect.com
The Horner-Wadsworth-Emmons reaction is one of the most reliable and widespread
synthetic tools for the stereocontrolled construction of ethylenic bonds. The versatility of the …

Radical Nitration-Debromination of α-Bromo-α-fluoroalkenes as a Stereoselective Route to Aromatic α-Fluoronitroalkenes Functionalized Fluorinated Building …

VA Motornov, VM Muzalevskiy, AA Tabolin… - The Journal of …, 2017 - ACS Publications
A new highly efficient method for the synthesis of 2-fluoro-2-nitrostyrenes was described.
Radical nitration of readily available 2-bromo-2-fluorostyrenes with Fe (NO3) 3· 9H2O …

Copper-mediated oxidative [3+ 2]-annulation of nitroalkenes and pyridinium ylides: general access to functionalized indolizines and efficient synthesis of 1 …

VA Motornov, AA Tabolin, YV Nelyubina… - Organic & …, 2019 - pubs.rsc.org
A general method for the synthesis of substituted indolizines by copper (II) acetate-promoted
oxidative [3+ 2]-annulation of α-fluoronitroalkenes with in situ generated pyridinium ylides …

Copper-mediated oxidative [3+ 2]-annulation of nitroalkenes and pyridinium imines: efficient synthesis of 3-fluoro-and 3-nitro-pyrazolo [1, 5-a] pyridines

VA Motornov, AA Tabolin, YV Nelyubina… - Organic & …, 2020 - pubs.rsc.org
An efficient route to pyrazolo [1, 5-a] pyridines by Cu (OAc) 2-promoted oxidative [3+ 2]-
annulation of nitroalkenes with in situ generated pyridinium imines is developed. The …

Cu-catalyzed cascade difluoroalkylation/5-endo cyclization/β-fluorine cleavage of ynones

J Su, W Guo, Y Liu, L Kong, H Zheng… - Chemical …, 2023 - pubs.rsc.org
A copper-catalyzed, redox-neutral cascade difluoroalkylation/5-endo annulation/β-fluorine
cleavage of ynones is developed, providing a direct and stereoselective method to access …