Automated detection and forecasting of covid-19 using deep learning techniques: A review
Abstract In March 2020, the World Health Organization (WHO) declared COVID-19 a global
epidemic, caused by the SARS-CoV-2 virus. Initially, COVID-19 was diagnosed using real …
epidemic, caused by the SARS-CoV-2 virus. Initially, COVID-19 was diagnosed using real …
Small drugs, huge impact: the extraordinary impact of antisense oligonucleotides in research and drug development
AM Quemener, ML Centomo, SL Sax, R Panella - Molecules, 2022 - mdpi.com
Antisense oligonucleotides (ASOs) are an increasingly represented class of drugs. These
small sequences of nucleotides are designed to precisely target other oligonucleotides …
small sequences of nucleotides are designed to precisely target other oligonucleotides …
Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome
PR Bhatt, A Scaiola, G Loughran, M Leibundgut… - Science, 2021 - science.org
Programmed ribosomal frameshifting is a key event during translation of the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome that allows synthesis of the …
respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome that allows synthesis of the …
Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements
I Manfredonia, C Nithin… - Nucleic acids …, 2020 - academic.oup.com
SARS-CoV-2 is a betacoronavirus with a linear single-stranded, positive-sense RNA
genome, whose outbreak caused the ongoing COVID-19 pandemic. The ability of …
genome, whose outbreak caused the ongoing COVID-19 pandemic. The ability of …
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms
Summary Severe-acute-respiratory-syndrome-related coronavirus 2 (SARS-CoV-2) is the
positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The genome …
positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The genome …
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
K Leppek, GW Byeon, W Kladwang… - Nature …, 2022 - nature.com
Therapeutic mRNAs and vaccines are being developed for a broad range of human
diseases, including COVID-19. However, their optimization is hindered by mRNA instability …
diseases, including COVID-19. However, their optimization is hindered by mRNA instability …
The architecture of the SARS-CoV-2 RNA genome inside virion
C Cao, Z Cai, X Xiao, J Rao, J Chen, N Hu… - Nature …, 2021 - nature.com
SARS-CoV-2 carries the largest single-stranded RNA genome and is the causal pathogen of
the ongoing COVID-19 pandemic. How the SARS-CoV-2 RNA genome is folded in the virion …
the ongoing COVID-19 pandemic. How the SARS-CoV-2 RNA genome is folded in the virion …
The short-and long-range RNA-RNA interactome of SARS-CoV-2
The Coronaviridae is a family of positive-strand RNA viruses that includes SARS-CoV-2, the
etiologic agent of the COVID-19 pandemic. Bearing the largest single-stranded RNA …
etiologic agent of the COVID-19 pandemic. Bearing the largest single-stranded RNA …
Targeting the SARS-CoV-2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders
COVID-19 is a global pandemic, thus requiring multiple strategies to develop modalities
against it. Herein, we designed multiple bioactive small molecules that target a functional …
against it. Herein, we designed multiple bioactive small molecules that target a functional …
Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy
The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2)
highlights the need for coordinated research to combat COVID-19. A particularly important …
highlights the need for coordinated research to combat COVID-19. A particularly important …