Antioxidant therapy: current status and future prospects

O Firuzi, R Miri, M Tavakkoli… - Current medicinal …, 2011 - ingentaconnect.com
Reactive oxygen species (ROS) are widely believed to cause or aggravate several human
pathologies such as neurodegenerative diseases, cancer, stroke and many other ailments …

Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities

RM Adibhatla, JF Hatcher - Antioxidants & redox signaling, 2010 - liebertpub.com
Reactive oxygen species (ROS) are produced at low levels in mammalian cells by various
metabolic processes, such as oxidative phosphorylation by the mitochondrial respiratory …

Survey on medicinal plants and herbs in traditional Iranian medicine with anti-oxidant, anti-viral, anti-microbial, and anti-inflammation properties

MH Shahrajabian, W Sun - Letters in Drug Design & Discovery, 2023 - ingentaconnect.com
The review aims to summarize the major and dominant natural antioxidants and their
resources from medicinal and herbal plants with antiviral, anti-inflammation and …

The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis

LE Padgett, KA Broniowska, PA Hansen… - Annals of the New …, 2013 - Wiley Online Library
Type 1 diabetes (T1D) is a T cell–mediated autoimmune disease characterized by the
destruction of insulin‐secreting pancreatic β cells. In humans with T1D and in nonobese …

Iron in multiple sclerosis: roles in neurodegeneration and repair

E Stephenson, N Nathoo, Y Mahjoub, JF Dunn… - Nature Reviews …, 2014 - nature.com
MRI and histological studies have shown global alterations in iron levels in the brains of
patients with multiple sclerosis (MS), including increases in the iron stored by macrophages …

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's …

DB Kell - Archives of toxicology, 2010 - Springer
Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

[HTML][HTML] Is multiple sclerosis a mitochondrial disease?

P Mao, PH Reddy - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2010 - Elsevier
Multiple sclerosis (MS) is a relatively common and etiologically unknown disease with no
cure treatment. It is the leading cause of neurological disability in young adults, affecting …

Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?

ME Witte, JJG Geurts, HE de Vries, P van der Valk… - Mitochondrion, 2010 - Elsevier
Dysfunctional mitochondria are thought to play a cardinal role in the pathogenesis of various
neurological disorders, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease …

Targeting Keap1/Nrf2/ARE signaling pathway in multiple sclerosis

D Michaličková, T Hrnčíř, NK Canová… - European journal of …, 2020 - Elsevier
Multiple sclerosis (MS) is a neurologic autoimmune disorder featured by chronic
inflammation of the central nervous system, demyelination and axonal damage. Recently …

Nox2 complex–derived ROS as immune regulators

O Sareila, T Kelkka, A Pizzolla, M Hultqvist… - Antioxidants & redox …, 2011 - liebertpub.com
Reactive oxygen species (ROS) are a heterogeneous group of highly reactive molecules
that oxidize targets in a biologic system. During steady-state conditions, ROS are constantly …