Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease

M Zhao, XF Jiang, HQ Zhang, JH Sun, H Pei… - Ageing research …, 2021 - Elsevier
Abstract Alzheimer's disease (AD), which is an irreversible neurodegenerative disorder
characterized by senile plaques and neurofibrillary tangles, is the most common form of …

Deep-brain optical recording of neural dynamics during behavior

ZC Zhou, A Gordon-Fennell, SC Piantadosi, N Ji… - Neuron, 2023 - cell.com
In vivo fluorescence recording techniques have produced landmark discoveries in
neuroscience, providing insight into how single cell and circuit-level computations mediate …

110 μm thin endo-microscope for deep-brain in vivo observations of neuronal connectivity, activity and blood flow dynamics

M Stibůrek, P Ondráčková, T Tučková, S Turtaev… - Nature …, 2023 - nature.com
Light-based in-vivo brain imaging relies on light transport over large distances of highly
scattering tissues. Scattering gradually reduces imaging contrast and resolution, making it …

In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse

AM Moore, LM Coolen… - Proceedings of the …, 2022 - National Acad Sciences
A hypothalamic pulse generator located in the arcuate nucleus controls episodic release of
gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) and is essential for …

Egocentric neural representation of geometric vertex in the retrosplenial cortex

K Park, Y Yeo, K Shin, J Kwag - Nature Communications, 2024 - nature.com
Egocentric neural representations of environmental features, such as edges and vertices,
are important for constructing a geometrically detailed egocentric cognitive map for goal …

Early Changes in Striatal Activity and Motor Kinematics in a Huntington's Disease Mouse Model

ET Koch, MD Sepers, J Cheng… - Movement …, 2022 - Wiley Online Library
Background Huntington's disease is a progressive neurodegenerative disorder with no
disease‐modifying treatments. Patients experience motor, cognitive, and psychiatric …

A miniature fluorescence microscope for multi-plane imaging

G Barbera, R Jun, Y Zhang, B Liang, Y Li, DT Lin - Scientific Reports, 2022 - nature.com
Miniature fluorescence microscopes are becoming an increasingly established tool to
investigate neural circuits in freely moving animals. In this work we present a lightweight one …

Memory encoding and retrieval by retrosplenial parvalbumin interneurons are impaired in Alzheimer's disease model mice

K Park, MM Kohl, J Kwag - Current Biology, 2024 - cell.com
Memory deficits in Alzheimer's disease (AD) show a strong link with GABAergic interneuron
dysfunctions. 1, 2, 3, 4, 5, 6, 7 The ensemble dynamics of GABAergic interneurons represent …

Kisspeptin neuron electrophysiology: Intrinsic properties, hormonal modulation, and regulation of homeostatic circuits

BB Jamieson, R Piet - Frontiers in Neuroendocrinology, 2022 - Elsevier
The obligatory role of kisspeptin (KISS1) and its receptor (KISS1R) in regulating the
hypothalamic-pituitary–gonadal axis, puberty and fertility was uncovered in 2003. In the few …

Memory reactivations during sleep

K Ghandour, K Inokuchi - Neuroscience Research, 2023 - Elsevier
Neuronal activities that occur during awake periods are often reactivated again during sleep,
to consolidate recently encoded memories, a process known as consolidation. In recent …