Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations
S Dai, L Qu, J Li, Y Chen - Nucleic acids research, 2021 - academic.oup.com
Forkhead box (FOX) proteins are an evolutionarily conserved family of transcription factors
that play numerous regulatory roles in eukaryotes during developmental and adult life …
that play numerous regulatory roles in eukaryotes during developmental and adult life …
Short tandem repeats bind transcription factors to tune eukaryotic gene expression
CA Horton, AM Alexandari, MGB Hayes, E Marklund… - Science, 2023 - science.org
Short tandem repeats (STRs) are enriched in eukaryotic cis-regulatory elements and alter
gene expression, yet how they regulate transcription remains unknown. We found that STRs …
gene expression, yet how they regulate transcription remains unknown. We found that STRs …
Genomic analysis of Foxp3 function in regulatory T cells
GA Dolsten, Y Pritykin - The Journal of Immunology, 2023 - journals.aai.org
Regulatory T (Treg) cells are critical for tolerance to self-antigens and for preventing
autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor …
autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor …
Novel insights from a multiomics dissection of the Hayflick limit
The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …
senescence has become a prominent model for cellular aging in vitro. Despite decades of …
The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis
FoxP3 is an essential transcription factor (TF) for immunologic homeostasis, but how it
utilizes the common forkhead DNA-binding domain (DBD) to perform its unique function …
utilizes the common forkhead DNA-binding domain (DBD) to perform its unique function …
Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions
Recent high-throughput transcription factor (TF) binding assays revealed that TF
cooperativity is a widespread phenomenon. However, a global mechanistic and functional …
cooperativity is a widespread phenomenon. However, a global mechanistic and functional …
FOXN3 and GDNF polymorphisms as common genetic factors of substance use and addictive behaviors
Epidemiological and phenomenological studies suggest shared underpinnings between
multiple addictive behaviors. The present genetic association study was conducted as part …
multiple addictive behaviors. The present genetic association study was conducted as part …
Mechanism of forkhead transcription factors binding to a novel palindromic DNA site
J Li, S Dai, X Chen, X Liang, L Qu, L Jiang… - Nucleic Acids …, 2021 - academic.oup.com
Forkhead transcription factors bind a canonical consensus DNA motif, RYAAAYA (R= A/G,
Y= C/T), as a monomer. However, the molecular mechanisms by which forkhead …
Y= C/T), as a monomer. However, the molecular mechanisms by which forkhead …
DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues
Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) among
eukaryotic sequence-specific transcription factors (TFs) and are the TF structural class with …
eukaryotic sequence-specific transcription factors (TFs) and are the TF structural class with …
Noncanonical binding of transcription factors: time to revisit specificity?
MAH Samee - Molecular Biology of the Cell, 2023 - Am Soc Cell Biol
Transcription factors (TFs) are one of the most studied classes of DNA-binding proteins that
have a direct functional impact on gene transcription and thus, on human physiology and …
have a direct functional impact on gene transcription and thus, on human physiology and …