Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

M Yuan, B Yang, G Rothschild, JJ Mann… - Signal transduction and …, 2023 - nature.com
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

[HTML][HTML] Sex differences in the blood–brain barrier: implications for mental health

L Dion-Albert, LB Binder, B Daigle, A Hong-Minh… - Frontiers in …, 2022 - Elsevier
Prevalence of mental disorders, including major depressive disorder (MDD), bipolar
disorder (BD) and schizophrenia (SZ) are increasing at alarming rates in our societies …

Neurobiological basis of increased risk for suicidal behaviour

A Wisłowska-Stanek, K Kołosowska, P Maciejak - Cells, 2021 - mdpi.com
According to the World Health Organization (WHO), more than 700,000 people die per year
due to suicide. Suicide risk factors include a previous suicide attempt and psychiatric …

A microRNA signature that correlates with cognition and is a target against cognitive decline

MR Islam, L Kaurani, T Berulava… - EMBO molecular …, 2021 - embopress.org
While some individuals age without pathological memory impairments, others develop age‐
associated cognitive diseases. Since changes in cognitive function develop slowly over time …

Baseline levels of miR-223-3p correlate with the effectiveness of electroconvulsive therapy in patients with major depression

L Kaurani, M Besse, I Methfessel, A Methi… - Translational …, 2023 - nature.com
There is a strong medical need to develop suitable biomarkers to improve the diagnosis and
treatment of depression, particularly in predicting response to certain therapeutic …

Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission

W Liang, Y Hou, W Huang, Y Wang, T Jiang… - Science …, 2022 - science.org
Schizophrenia is a polygenetic disease, the heterogeneity of which is likely complicated by
epigenetic modifications yet to be elucidated. Here, we performed transcriptomic analysis of …

Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice

L Kaurani, MR Islam, U Heilbronner, DM Krüger… - The EMBO …, 2024 - embopress.org
Current approaches to the treatment of schizophrenia have mainly focused on the protein-
coding part of the genome; in this context, the roles of microRNAs have received less …

Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury

Z Zhu, X Huang, M Du, C Wu, J Fu, W Tan, B Wu… - Molecular …, 2023 - nature.com
Post-traumatic stress disorder (PTSD) is usually considered a psychiatric disorder upon
emotional trauma. However, with the rising number of conflicts and traffic accidents around …

MicroRNAs as critical biomarkers of major depressive disorder: a comprehensive perspective

MA Ortega, MA Alvarez-Mon, C García-Montero… - Biomedicines, 2021 - mdpi.com
Major Depressive Disorder (MDD) represents a major global health concern, a body-mind
malady of rising prevalence worldwide nowadays. The complex network of mechanisms …

Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms linking mood, metabolism and medicines

A Gangopadhyay, R Ibrahim, K Theberge… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
in the world and one of the leading indications for liver transplantation. It is one of the many …