Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Loss of functional β-cell mass is the key mechanism leading to the two main forms of
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …

Abstract Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells.
Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we …

Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme
type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the …

Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β
cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced …

We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date
(61,427 participants), yielding 78 genome-wide-significant (P< 5× 10− 8) regions, including …

It is increasingly appreciated that the pathogenic mechanisms of type 1 diabetes involve
both the autoimmune aggressors and their beta cell targets, which engage in a conflicting …

Abstract Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic
individuals, and its expression and signaling are regulated by T1D genetic risk variants and …

Type 1 diabetes (T1D) is an autoimmune disease characterized by the T-cell-mediated
destruction of insulin-producing β-cells in pancreatic islets. It generally occurs in genetically …

Abstract Background Type 1 diabetes (T1D) results from immune-mediated destruction of
insulin-producing beta cells. Prevention efforts have focused on immune modulation and …