Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …

Human African Trypanosomiasis (HAT, sleeping sickness) and Animal African
Trypanosomiasis (AAT) are neglected tropical diseases generally caused by the same …

Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both
rural and urban areas. CD was first described over a century ago, but only two drugs are …

Neglected Tropical Diseases (NTD) represent a serious threat to humans, especially for
those living in poor or developing countries. Almost one-sixth of the world population is at …

Abstract Chagas disease and Human African trypanosomiasis (HAT) are caused by
Trypanosoma cruzi, T. brucei rhodesiense or T. b. gambiense parasites, respectively; while …

American trypanosomiasis is a worldwide health problem that requires attention due to
ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1 …

Chagas disease, caused by Trypanosoma cruzi (T. cruzi), affects nearly eight million people
worldwide. There are currently only limited treatment options, which cause several side …

To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this
study, a set of new amino naphthoquinone derivatives were synthesised and evaluated in …

Abstract Trypanothione (T (SH) 2) is the main antioxidant metabolite for peroxide reduction
in Trypanosoma cruzi; therefore, its metabolism has attracted attention for therapeutic …

The protozoa, Trypanosoma cruzi (etiological agent of Chagas diseases–also named
American trypanosomiasis) and T. brucei (causative agent of human African …