The HIV-1 capsid, composed of approximately 1,200 copies of the capsid protein, encases
genomic RNA alongside viral nucleocapsid, reverse transcriptase, and integrase proteins …

The dynamic spatial organization of genomes across time, referred to as the four-
dimensional nucleome (4DN), is a key component of gene regulation and biological fate …

Host restriction factors play key roles in innate antiviral defense, but it remains poorly
understood which of them restricts HIV-1 in vivo. Here, we used single-cell transcriptomic …

Multiple cellular HIV reservoirs in diverse anatomical sites can undergo clonal expansion
and persist for years despite suppressive antiretroviral therapy, posing a major barrier …

To explore genome organization and function in the HIV-infected brain, we applied single-
nuclei transcriptomics, cell-type-specific chromosomal conformation mapping, and viral …

Human immunodeficiency virus (HIV) infection is the cause of acquired immunodeficiency
syndrome (AIDS). Combination antiretroviral therapy (cART) has successfully controlled …

Genetically intact HIV-1 proviruses are a major concern with regard to curing infection
because they cause viral rebound after the cessation of antiretroviral therapy. However …

Eukaryotic chromatin is highly organized in the 3D nuclear space and dynamically regulated
in response to environmental stimuli. This genomic organization is arranged in a …

Understanding the mechanisms that drive HIV expression and latency is a key goal for
achieving an HIV cure. Here we investigate the role of the SETD2 histone methyltransferase …

Transcriptionally latent forms of replication-competent proviruses, present primarily in a
small subset of memory CD4+ T cells, pose the primary barrier to a cure for HIV-1 infection …