A mechanistic insight into protein-ligand interaction, folding, misfolding, aggregation and inhibition of protein aggregates: An overview

TI Chandel, M Zaman, MV Khan, M Ali… - International journal of …, 2018 - Elsevier
This review article summarises the possible mechanisms of the protein-ligand interaction,
folding, misfolding, aggregation and inhibition of protein aggregates. Under certain stressed …

Proteomics analysis of human serum of patients with non‐small‐cell lung cancer reveals proteins as diagnostic biomarker candidates

M Boccellino, F Pinto, V Ieluzzi… - Journal of Cellular …, 2019 - Wiley Online Library
Non‐small‐cell lung carcinomas (NSCLC) is the most common type of lung cancer and it
has a poor prognosis, because overall survival after 5 years is 20–25% for all stages. Thus …

Insight into the molecular interaction between the anticancer drug, enzalutamide and human alpha-2-macroglobulin: Biochemical and biophysical approach

MK Zia, T Siddiqui, S Ansari, M Muaz, H Ahsan… - … Acta Part A: Molecular …, 2024 - Elsevier
The drug pharmacokinetics is affected upon binding with proteins, thus making drug-protein
interactions crucial. This study investigated the interaction between enzalutamide and …

Interaction of anti-cancer drug-cisplatin with major proteinase inhibitor-alpha-2-macroglobulin: Biophysical and thermodynamic analysis

MK Zia, T Siddiqui, SS Ali, H Ahsan, FH Khan - International journal of …, 2018 - Elsevier
Alpha-2-macroglobulin is a multifunctional, highly abundant, plasma protein which reacts
with a wide variety of molecules and drugs including cisplatin. Cisplatin is commonly used …

Engineered β-hairpin scaffolds from human prion protein regions: Structural and functional investigations of aggregates

C Di Natale, S La Manna, C Avitabile, D Florio… - Bioorganic …, 2020 - Elsevier
The investigation of conformational features of regions of amyloidogenic proteins are of
great interest to deepen the structural changes and consequent self-aggregation …

Exploring the interaction of anti-androgen drug-bicalutamide with human alpha-2-macroglobulin: A biophysical investigation

MK Zia, T Siddiqui, SS Ali, H Ahsan, FH Khan - International journal of …, 2018 - Elsevier
Bicalutamide (BCT), a drug used in the treatment of prostate cancer, antagonises the actions
of androgens, at the receptor level, thereby inhibiting the growth of prostate tumours. Alpha …

[HTML][HTML] A novel magnetoelastic biosensor consisting of carbon quantum dots/nitrocellulose membranes and NiFe2O4/polylactic acid based on 3D printing for α2 …

X Guo, Z Wang, J Hou, Q Duan, J Ji, Y Ge… - Chinese Journal of …, 2024 - Elsevier
Abstract α2-macroglobulin (α2-M) have crucial clinical significance as a potent biomarker for
diabetes nephropathy (DN). There is an increasing demand for rapid detection of α2-M …

Effect of α2‑macroglobulin in the early stage of jaw osteoradionecrosis

J Li, P Yin, X Chen, X Kong… - International …, 2020 - spandidos-publications.com
Advanced osteoradionecrosis (ORN) is one of the most serious complications in patients
with head and neck cancer, resulting in poor prognosis. Numerous studies have therefore …

[HTML][HTML] Protective effects of α‑2‑macroglobulin on human bone marrow mesenchymal stem cells in radiation injury

Y Liu, W Cao, X Kong, J Li, X Chen… - Molecular …, 2018 - spandidos-publications.com
Osteoradionecrosis of the jaws (ORNJ) is a complication of oral and maxillofacial
malignancy that arises following radiotherapy; progressive jaw necrosis severely decreases …

Solution NMR structure of cementum protein 1 derived peptide (CEMP1‐p1) and its role in the mineralization process

MN Campos, EL Giraldo… - Journal of Peptide …, 2023 - Wiley Online Library
We report the characterization of the three‐dimensional structure of the CEMP1‐p1 peptide [
MGTSSTDSQQAQHRRCSTSN: corresponding to residues 1–20 of the N‐terminus of …