The cross‐linking of structural extracellular matrix (ECM) components, especially fibrillar
collagens and elastin, is strongly implicated in fibrosis progression and resistance to fibrosis …

Objective Fibrosis stage is strongly associated with liver-related outcomes and is a key
surrogate endpoint in drug trials for non-alcoholic steatohepatitis. Dual-photon microscopy …

Elastin is an amorphous protein highly resistant to elastase degradation and is believed to
be the most stable component among the extracellular matrix (ECM) members. Thus the …

Background & Aims Hepatic fibrosis is characterized by hepatic stellate cell (HSC) activation
and transdifferentiation-mediated extracellular matrix (ECM) deposition, which both …

Monitoring longitudinal nonadvanced fibrosis is a more common scenario in management of
chronic hepatitis B (CHB), for which, however, current evaluation methods generally lack …

English Liver fibrogenesis is a common pathway of pathological progression of chronic liver
injuries. The diagnosis of liver fibrosis provides an important basis for treatment decision …

Liver fibrogenesis is a common pathway of pathological progression of chronic liver injuries.
The diagnosis of liver fibrosis provides an important basis for treatment decision-making and …

非酒精性脂肪性肝病(NAFLD) 正逐渐成为慢性肝病肝纤维化发生的首要原因.
组织学肝纤维化可能是目前对NAFLD 预后进行判断的最重要独立影响因素. NAFLD …

Nonalcoholic fatty liver disease (NAFLD) is becoming a primary etiology underlying the
chronic liver injury-related fibrogenesis among general population. Histologic fibrosis has …