Synergy by perturbing the gram-negative outer membrane: opening the door for gram-positive specific antibiotics

CMJ Wesseling, NI Martin - ACS Infectious Diseases, 2022 - ACS Publications
New approaches to target antibacterial agents toward Gram-negative bacteria are key, given
the rise of antibiotic resistance. Since the discovery of polymyxin B nonapeptide as a potent …

New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance

K Klobucar, ED Brown - Current Opinion in Chemical Biology, 2022 - Elsevier
Because of the rise in antibiotic resistance and the dwindling pipeline of effective antibiotics,
it is imperative to explore avenues that breathe new life into existing drugs. This is …

Effect of hydrophobic groups on antimicrobial and hemolytic activity: Developing a predictive tool for ternary antimicrobial polymers

PT Phuong, S Oliver, J He, EHH Wong… - …, 2020 - ACS Publications
Antimicrobial polymers have emerged as a potential solution to the growing problem of
antimicrobial resistance. Although several studies have examined the effects of various …

Antibacterial and Biofilm-Eradicating Activities of pH-Responsive Vesicles against Pseudomonas aeruginosa

S Cui, J Qiao, MP Xiong - Molecular Pharmaceutics, 2022 - ACS Publications
The formation of biofilms by a microcolony of bacteria is a significant burden on the
healthcare industry due to difficulty eradicating it. In this study, pH-responsive vesicles …

Synthesis and evaluation of an amphiphilic deferoxamine: gallium-conjugated cationic random copolymer against a murine wound healing infection model of …

J Qiao, Z Liu, S Cui, T Nagy, MP Xiong - Acta biomaterialia, 2021 - Elsevier
Multidrug resistant (MDR) Gram-negative bacteria are an urgent global health threat. We
report on the design and evaluation of a xenosiderophore-conjugated cationic random …

ROS-sensitive micelles for controlled delivery of antibiotics to combat intracellular Staphylococcus aureus-associated infections

J Qiao, S Cui, MP Xiong - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
Bacteria can evade the immune system once they are engulfed by phagocytic host cells.
This protects them against the bactericidal action of antibiotics and allows the infection to …

Antibacterial and degradable thioimidazolium poly (ionic liquid)

CA Smith, VA Cataldo, T Dimke, I Stephan… - ACS Sustainable …, 2020 - ACS Publications
New antibacterial agents are urgently required to fight the emergence of antibiotic-resistant
bacteria. We recently synthesized the first thioimidazolium ionene, which has antibacterial …

Особенности неспецифической резистентности при ожоговой травме: патофизиологическая оценка (обзор)

АВ Перешеин, СВ Кузнецова… - Современные …, 2020 - cyberleninka.ru
Проведен анализ современных сведений о состоянии неспецифической
резистентности у ожоговых пациентов. Рассматриваются проблемы оценки функций …

Bio-based nonionic antimicrobial polymers with isatin or indole functionality

X Li - 2021 - portal.research.lu.se
Infections by pathogenic microorganisms remain one of the most serious concerns in
several areas, particularly in hygienic applications. Antimicrobials have been used to …

[PDF][PDF] Potentiation of Gram-positi e specific antibiotics against Gram-negati e bacteria through outer membrane disruption

CM Wesseling - scholarlypublications …
The increasing occurrence of antibiotic resistance among Gram-negative pathogens
highlights the need for novel antibacterial agents and therapeutic strategies. It is well …