The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …

Maintenance of homeostatic immune surveillance and development of effective adaptive
immune responses require precise regulation of spatial and temporal lymphocyte trafficking …

The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue
growth two decades ago and has been a subject extensively studied in both Drosophila and …

Integrins are a family of heterodimeric receptors that bind to components of the extracellular
matrix and influence cellular processes as varied as proliferation and migration. These …

Adoptive transfer of genetically engineered chimeric antigen receptor (CAR) T cells is
becoming a promising treatment option for hematological malignancies. However, T cell …

An imbalance in the lineages of immunosuppressive regulatory T cells (Treg cells) and the
inflammatory TH17 subset of helper T cells leads to the development of autoimmune and/or …

Since its discovery, the Hippo pathway has emerged as a central signaling network in
mammalian cells. Canonical signaling through the Hippo pathway core components …

β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

Pathogen-mediated activation of macrophages arms innate immune responses that include
enhanced surface ruffling and macropinocytosis for environmental sampling and receptor …

Dynamic localization of receptors and signaling molecules at the plasma membrane and
within intracellular vesicular compartments is crucial for T lymphocyte sensing …