Cytokines are important modulators of inflammation. The balance between pro-and anti-
inflammatory cytokines determines whether the intensity of inflammatory response is within …

Schönlein-Henoch syndrome is a form of systemic small-vessel vasculitis, characterised by
vascular and/or mesangial immunoglobulin A1 deposits. The main clinical manifestations …

Interferon-γ inhibits experimental renal fibrosis. Background Recent evidence has implicated
myofibroblasts as a cell type responsible for the laying down of extracellular matrix …

Mesangial cell (MC) proliferation and extracellular matrix expansion are involved in the
pathogenesis of glomerulosclerosis and renal failure. In vitro, PDGF and basic fibroblast …

Although a lot of animal models of proteinuria have been established, proposals for the
mechanisms of proteinuria are still controversial. In this work, during an 18-day trial, mice …

Renal reactive oxygen species (ROS) and mononuclear leukocyte infiltration are involved in
the progressive stage (exacerbation) of IgA nephropathy (IgAN), which is characterized by …

Background. Kidneys that progress to end‐stage renal failure are almost invariably
characterized by the presence of tubulointerstitial fibrosis. Therapeutic interventions to halt …

IgA nephropathy (IgAN) is the most common type of glomerulonephritis that frequently
progresses to kidney failure. However, the molecular pathogenesis underlying IgAN remains …

Background. IL-1β has the potential to promote progressive renal disease by effects on
macrophage recruitment and activation or by effects mediated through tubular cell …

IMMUNOGLOBULIN A nephropathy (IgAN) is defined as glomerulonephritis (GN) in which
IgA is the predominant immunoglobulin deposited in the glomerulus. 1-5 In addition to …