Tissue-resident memory T (TRM) cells are populations which settle down in non-lymphoid
tissues instead of returning to secondary lymph organs after the antigen presentation. These …

Background Machine learning (ML) has emerged as a vital asset for researchers to analyze
and extract valuable information from complex datasets. However, developing an effective …

Oncolytic viruses (OVs) emerge as a promising cancer immunotherapy. However, the
temporal impact on tumor cells and the tumor microenvironment, and the nature of anti …

Background Melanoma, the most lethal form of skin cancer, has undergone a transformative
treatment shift with the advent of checkpoint blockade immunotherapy (CBI). Understanding …

The magnitude of the effector functions of memory T cells determines the consequences of
the protection against invading pathogens and tumor development or the pathogenesis of …

Resident memory T cells (T RM s) help control local immune homeostasis and contribute to
tissue-protective immune responses. The local cues that guide their differentiation and …

Abstract IL-21/IL-21R signaling dysregulation is linked to multiple chronic intestinal
inflammatory disorders in humans and animal models of human diseases. In addition to its …

BCL11b is a transcription regulator and a tumor suppressor involved in lymphomagenesis,
central nervous system (CNS) and immune system developments. BCL11b favors …