Integrins are heterodimeric transmembrane cell adhesion molecules made up of alpha (α)
and beta (β) subunits arranged in numerous dimeric pairings. These complexes have …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Integrins are large, membrane-spanning, heterodimeric proteins that are essential for a
metazoan existence. All members of the integrin family adopt a shape that resembles a large …

Integrins are cell adhesion receptors that are evolutionary old and that play important roles
during developmental and pathological processes. The integrin family is composed of 24 αβ …

In their roles as major adhesion receptors, integrins signal across the plasma membrane in
both directions. Recent structural and cell biological data suggest models for how integrins …

Formation of distant metastases is by far the most common cause of cancer-related deaths.
The process of metastasis formation is complex, and within this complex process the …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …

The structural basis for the divalent cation–dependent binding of heterodimeric αβ integrins
to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown …

The “integrin” terminology was applied in a 1987 review article (1) to describe a family of
structurally, immunochemically, and functionally related cell-surface heterodimeric …