From Shallow to Deep Bioprocess Hybrid Modeling: Advances and Future Perspectives

R Agharafeie, JRC Ramos, JM Mendes, R Oliveira - Fermentation, 2023 - mdpi.com
Deep learning is emerging in many industrial sectors in hand with big data analytics to
streamline production. In the biomanufacturing sector, big data infrastructure is lagging …

Toward a modeling, optimization, and predictive control framework for fed‐batch metabolic cybergenetics

S Espinel‐Ríos, B Morabito, J Pohlodek… - Biotechnology and …, 2024 - Wiley Online Library
Biotechnology offers many opportunities for the sustainable manufacturing of valuable
products. The toolbox to optimize bioprocesses includes extracellular process elements …

[HTML][HTML] Experimentally implemented dynamic optogenetic optimization of ATPase expression using knowledge-based and Gaussian-process-supported models

S Espinel-Ríos, G Behrendt, J Bauer, B Morabito… - Process …, 2024 - Elsevier
Optogenetic modulation of adenosine triphosphatase (ATPase) expression represents a
novel approach to maximize bioprocess efficiency by leveraging enforced adenosine …

Machine learning for process control of (bio) chemical processes

A Himmel, J Matschek, R Kok, B Morabito… - arXiv preprint arXiv …, 2023 - arxiv.org
The control of manufacturing processes must satisfy high quality and efficiency requirements
while meeting safety requirements. A broad spectrum of monitoring and control strategies …

Machine learning for control of (bio) chemical manufacturing systems

A Himmel, J Matschek, R Kok, B Morabito… - Artificial Intelligence in …, 2024 - Elsevier
The control of manufacturing processes must satisfy high-quality and efficiency requirements
while meeting safety requirements. A broad spectrum of monitoring and control strategies …

Modeling, optimization, and predictive control for metabolic cybergenetics

S Espinel Ríos - 2023 - repo.bibliothek.uni-halle.de
This thesis outlines a framework for metabolic cybergenetics that employs computational
methods to control gene expression of metabolism-relevant enzymes via external signals …

[PDF][PDF] Modeling, optimization, and predictive control for metabolic cybergenetics

IS Klamt, IR Findeisen, IS Waldherr - opendata.uni-halle.de
This thesis outlines a framework for metabolic cybergenetics that employs computational
methods to control gene expression of metabolism-relevant enzymes via external signals …