In the past decade, relative proteomic quantification using isobaric labeling technology has
developed into a key tool for comparing the expression of proteins in biological samples …

Protein interactions underlie most molecular events in biology. Many methods have been
developed to identify protein partners, to measure the affinity with which these biomolecules …

The phytohormone auxin triggers transcriptional reprogramming through a well-
characterized perception machinery in the nucleus. By contrast, mechanisms that underlie …

Protein structure and function is determined by the arrangement of the linear sequence of
amino acids in 3D space. We show that a deep graph neural network, ProteinSolver, can …

Circular dichroism (CD) spectroscopy is widely used to characterize the secondary structure
composition of proteins. To derive accurate and detailed structural information from the CD …

Mutations in the tumor suppressor SPOP (speckle-type POZ protein) cause prostate, breast,
and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and …

Amyloids are ordered protein aggregates, found in all kingdoms of life, and are involved in
aggregation diseases as well as in physiological activities. In microbes, functional amyloids …

Far-UV circular dichroism (CD) spectroscopy is a classical method for the study of the
secondary structure of polypeptides in solution. It has been the general view that the α-helix …

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of dopamine
(DA) and other catecholamines, and its dysfunction leads to DA deficiency and …

Intrinsically disordered proteins (IDPs) are comprised of significant numbers of residues that
form neither helix, sheet, nor any other canonical type of secondary structure. They play …