Histone deacetylase (HDAC) 6 is the best‐characterized class II b deacetylase that
regulates many important biological processes via the formation of complexes with its …

The class of muscular dystrophies linked to the genetic ablation or mutation of dysferlin,
including Limb Girdle Muscular Dystrophy 2B (LGMD2B) and Miyoshi Myopathy (MM), are …

Tubulin undergoes posttranslational modifications proposed to specify microtubule
subpopulations for particular functions. Most of these modifications occur on the C-termini of …

Dysferlinopathies, most commonly limb girdle muscular dystrophy 2B and Miyoshi
myopathy, are degenerative myopathies caused by mutations in the DYSF gene encoding …

Little is known about the function of the cytoplasmic histone deacetylase HDAC6 in striated
muscle. Here, we addressed the role of HDAC6 in cardiac and skeletal muscle remodeling …

Protein aggregates can form in the cytoplasm of the cell and are accumulated at
aggresomes localized to the microtubule organizing center (MTOC) where they are …

The αβ-tubulin subunits of microtubules can undergo a variety of evolutionarily-conserved
post-translational modifications (PTMs) that provide functional specialization to subsets of …

The special class IIb histone deacetylase, HDAC6, plays a prominent role in many cellular
processes related to cancer, including oncogenesis, the cell stress response, motility, and …

Cytoplasmic localization and possession of two deacetylase domains and a ubiquitin-
binding domain make histone deacetylase 6 (HDAC6) a unique histone deacetylase …

Alterations of the epigenetic machinery, affecting multiple biological functions, represent a
major hallmark enabling the development of tumors. Among epigenetic regulatory proteins …