Sepsis, severe sepsis, and septic shock represent increasingly severe systemic
inflammatory responses to infection. Sepsis is common in the aging population, and it …

Severe sepsis is a leading cause of death in the United States and the most common cause
of death among critically ill patients in non-coronary intensive care units (ICU). Respiratory …

Importance The Third International Consensus Definitions Task Force defined sepsis as “life-
threatening organ dysfunction due to a dysregulated host response to infection.” The …

Rationale: Reducing the global burden of sepsis, a recognized global health challenge,
requires comprehensive data on the incidence and mortality on a global scale. Objectives …

Importance End-of-life care costs are high and decedents often experience poor quality of
care. Numerous factors influence changes in site of death, health care transitions, and …

Objectives To ascertain the absolute number of M edicare beneficiaries surviving at least 3
years after severe sepsis and to estimate their burden of cognitive dysfunction and disability …

Context Severe sepsis, defined as infection complicated by acute organ dysfunction, occurs
more frequently and leads to more deaths in black than in white individuals. The optimal …

Rationale: Crisis standards of care (CSCs) guide critical care resource allocation during
crises. Most recommend ranking patients on the basis of their expected in-hospital mortality …

Background Critically ill patients are medically complex and may benefit from a
multidisciplinary approach to care. Methods We conducted a population-based retrospective …

Background: Severe sepsis is a common and costly problem. Although consistently defined
clinically by consensus conference since 1991, there have been several different …