The quest for mammalian Polycomb response elements: are we there yet?
M Bauer, J Trupke, L Ringrose - Chromosoma, 2016 - Springer
A long-standing mystery in the field of Polycomb and Trithorax regulation is how these
proteins, which are highly conserved between flies and mammals, can regulate several …
proteins, which are highly conserved between flies and mammals, can regulate several …
Context-dependent actions of Polycomb repressors in cancer
M Koppens, M Van Lohuizen - Oncogene, 2016 - nature.com
Abstract Polycomb Group (PcG) proteins form Polycomb Repressive Complexes (PRCs) that
function as epigenetic repressors of gene expression. The large variety of PcG proteins, in …
function as epigenetic repressors of gene expression. The large variety of PcG proteins, in …
Histone H3 mutations—a special role for H3. 3 in tumorigenesis?
S Kallappagoudar, RK Yadav, BR Lowe, JF Partridge - Chromosoma, 2015 - Springer
Brain tumors are the most common solid tumors in children. Pediatric high-grade glioma
(HGG) accounts for∼ 8–12% of these brain tumors and is a devastating disease as 70–90 …
(HGG) accounts for∼ 8–12% of these brain tumors and is a devastating disease as 70–90 …
Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins
R Ma, Y Zhang, T Sun, B Cheng - Journal of Zhejiang University Science B, 2014 - Springer
Polycomb group (PcG) complexes are epigenetic regulatory complexes that conduct
transcriptional repression of target genes via modifying the chromatin. The two best …
transcriptional repression of target genes via modifying the chromatin. The two best …
Yin Yang 1 controls cerebellar astrocyte maturation
K Mockenhaupt, KM Tyc, A McQuiston, AK Gonsiewski… - Glia, 2023 - Wiley Online Library
Diverse subpopulations of astrocytes tile different brain regions to accommodate local
requirements of neurons and associated neuronal circuits. Nevertheless, molecular …
requirements of neurons and associated neuronal circuits. Nevertheless, molecular …
Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs
LK Svoboda, A Harris, NJ Bailey, R Schwentner… - Epigenetics, 2014 - Taylor & Francis
The polycomb proteins BMI-1 and EZH2 are highly overexpressed by Ewing sarcoma (ES),
a tumor of stem cell origin that is driven by EWS-ETS fusion oncogenes, most commonly …
a tumor of stem cell origin that is driven by EWS-ETS fusion oncogenes, most commonly …
Epigenetic inheritance of cell fates during embryonic development
S Cheedipudi, O Genolet, G Dobreva - Frontiers in genetics, 2014 - frontiersin.org
During embryonic development a large number of widely differing and specialized cell types
with identical genomes are generated from a single totipotent zygote. Tissue specific …
with identical genomes are generated from a single totipotent zygote. Tissue specific …
Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes
Polycomb repressive complex-1 (PRC1) is essential for the epigenetic regulation of gene
expression. SCML2 is a mammalian homolog of Drosophila SCM, a Polycomb-group protein …
expression. SCML2 is a mammalian homolog of Drosophila SCM, a Polycomb-group protein …
Identification of a polycomb responsive region in human HoxA cluster and its long-range interaction with polycomb enriched genomic regions
A Verma, R Arya, V Brahmachari - Gene, 2022 - Elsevier
Polycomb and Trithorax group proteins (PcG, TrxG) epigenetically regulate developmental
genes. These proteins bind with specific DNA elements, the Polycomb Response Element …
genes. These proteins bind with specific DNA elements, the Polycomb Response Element …
Three classes of response elements for human PRC2 and MLL1/2–Trithorax complexes
Abstract Polycomb group (PcG) and Trithorax group (TrxG) proteins are essential for
maintaining epigenetic memory in both embryonic stem cells and differentiated cells. To …
maintaining epigenetic memory in both embryonic stem cells and differentiated cells. To …