Synthetic genomics is the construction of viruses, bacteria, and eukaryotic cells with
synthetic genomes. It involves two basic processes: synthesis of complete genomes or …

Valvular heart diseases (VHDs) are currently treated using either mechanical or
bioprosthetic heart valves. Unfortunately, mechanical valves require lifelong anticoagulation …

Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

Background Regenerative medicine has the potential to treat genetic disorders and replace
damaged or missing tissue. The use of donor or animal tissue raises many well-known …

Although the burden of end-stage heart failure continues to increase, the number of
available organs for heart transplantation (HT) remains inadequate. The HT community has …

The chronic rejection responses and side effects of the systematic administration of
immunosuppressants are the main obstacles to heart allograft and patient survival. The …

Despite increasing efforts by research and policy to approach sustainability, human impact
on nonhuman nature is intensifying the current social-ecological crisis. To foster …

Gene therapy has become a clinical reality as market-approved advanced therapy medicinal
products for the treatment of distinct monogenetic diseases and B-cell malignancies. This …