[HTML][HTML] Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an …
S Gonzalez, TLM McHugh, T Yang, W Syriani… - Neurobiology of …, 2022 - Elsevier
Degeneration of basal forebrain cholinergic neurons (BFCNs) in the nucleus basalis of
Meynert (NBM) and vertical diagonal band (VDB) along with their connections is a key …
Meynert (NBM) and vertical diagonal band (VDB) along with their connections is a key …
Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome
Dravet syndrome (DS) is one of the most severe childhood epilepsies, characterized by
intractable seizures and comorbidities including cognitive and social dysfunction and high …
intractable seizures and comorbidities including cognitive and social dysfunction and high …
Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury
JL Fletcher, LK Dill, RJ Wood, S Wang… - Experimental …, 2021 - Elsevier
Young children have a high risk of sustaining a traumatic brain injury (TBI), which can have
debilitating life-long consequences. Importantly, the young brain shows particular …
debilitating life-long consequences. Importantly, the young brain shows particular …
Brain-derived neurotrophic factor scales presynaptic calcium transients to modulate excitatory neurotransmission
CS Wang, CI McCarthy… - Proceedings of the …, 2024 - National Acad Sciences
Brain-derived neurotrophic factor (BDNF) plays a critical role in synaptic physiology, as well
as mechanisms underlying various neuropsychiatric diseases and their treatment. Despite …
as mechanisms underlying various neuropsychiatric diseases and their treatment. Despite …
Neurotrophins and neural stem cells in posttraumatic brain injury repair
W Guo, K Liu, Y Wang, X Ge, Y Ma, J Qin… - Animal Models and …, 2024 - Wiley Online Library
Traumatic brain injury (TBI) is the main cause of disability, mental health disorder, and even
death, with its incidence and social costs rising steadily. Although different treatment …
death, with its incidence and social costs rising steadily. Although different treatment …
[HTML][HTML] Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma
Thrombospondins (TSPs) are astrocyte-secreted extracellular matrix proteins that play key
roles as regulators of synaptogenesis in the central nervous system. We previously showed …
roles as regulators of synaptogenesis in the central nervous system. We previously showed …