Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors
Human immunodeficiency virus (HIV) causes approximately 2.5 million new infections every
year, and nearly 1.6 million patients succumb to HIV each year. Several factors, including …
year, and nearly 1.6 million patients succumb to HIV each year. Several factors, including …
Impact of drug resistance-associated amino acid changes in HIV-1 subtype C on susceptibility to newer nonnucleoside reverse transcriptase inhibitors
AE Basson, SY Rhee, CM Parry… - Antimicrobial agents …, 2015 - Am Soc Microbiol
The objective of this study was to assess the phenotypic susceptibility of HIV-1 subtype C
isolates, with nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance-associated …
isolates, with nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance-associated …
HIV behind bars: human immunodeficiency virus cluster analysis and drug resistance in a reference correctional unit from southern Brazil
IM Prellwitz, BM Alves, MLR Ikeda, D Kuhleis… - PloS one, 2013 - journals.plos.org
People deprived of liberty in prisons are at higher risk of infection by the human
immunodeficiency virus (HIV) due to their increased exposure through intravenous drug use …
immunodeficiency virus (HIV) due to their increased exposure through intravenous drug use …
Genetic diversity in the partial sequence of the HIV-1 gag gene among people living with multidrug-resistant HIV-1 infection
The group-specific antigen (gag) plays a crucial role in the assembly, release, and
maturation of HIV. This study aimed to analyze the partial sequence of the HIV gag gene to …
maturation of HIV. This study aimed to analyze the partial sequence of the HIV gag gene to …
The connection domain mutation N348I in HIV-1 reverse transcriptase enhances resistance to etravirine and rilpivirine but restricts the emergence of the E138K …
HT Xu, SP Colby-Germinario, M Oliveira, Y Han… - Journal of …, 2014 - Am Soc Microbiol
Clinical resistance to rilpivirine (RPV), a novel nonnucleoside reverse transcriptase (RT)
inhibitor (NNRTI), is associated an E-to-K mutation at position 138 (E138K) in RT together …
inhibitor (NNRTI), is associated an E-to-K mutation at position 138 (E138K) in RT together …
A polymorphism at position 400 in the connection subdomain of HIV-1 reverse transcriptase affects sensitivity to NNRTIs and RNaseH activity
DW Wright, IP Deuzing, P Flandre, P van den Eede… - PLoS …, 2013 - journals.plos.org
Reverse transcriptase (RT) plays an essential role in HIV-1 replication, and inhibition of this
enzyme is a key component of HIV-treatment. However, the use of RT inhibitors can lead to …
enzyme is a key component of HIV-treatment. However, the use of RT inhibitors can lead to …
Extensive variation in drug-resistance mutational profile of Brazilian patients failing antiretroviral therapy in five large Brazilian cities
C Brites, L Pinto-Neto, M Medeiros, E Nunes… - Brazilian Journal of …, 2016 - SciELO Brasil
Background Development of drug-resistance mutations is the main cause of failure in
antiretroviral therapy. In Brazil, there is scarce information on resistance pattern for patients …
antiretroviral therapy. In Brazil, there is scarce information on resistance pattern for patients …
Substitutions of rtL228 and/or L229 are involved in the regulation of replication and HBsAg secretion in hepatitis B virus, and do not affect susceptibility to nucleos (t) …
B Qin, Y Zhou, G Zhou, X Xu… - Molecular Medicine …, 2017 - spandidos-publications.com
Nucleos (t) ide analogs (NAs) are widely used in the treatment of hepatitis B virus (HBV) and
human immunodeficiency virus (HIV). The mutation L210W of HIV‑1 reverse transcriptase …
human immunodeficiency virus (HIV). The mutation L210W of HIV‑1 reverse transcriptase …
Drug resistance-related mutations T369V/I in the connection subdomain of HIV-1 reverse transcriptase severely impair viral fitness
Z Wang, J Zhang, F Li, X Ji, L Liao, L Ma, H Xing… - Virus Research, 2017 - Elsevier
Fitness is a key parameter in the measurement of transmission capacity of individual drug-
resistant HIV. Drug-resistance related mutations (DRMs) T369V/I and A371V in the …
resistant HIV. Drug-resistance related mutations (DRMs) T369V/I and A371V in the …
Etude des résistances du VIH-1 au traitement antirétroviral et amélioration du suivi virologique des patients vivant avec le VIH dans les pays du Sud
E Guichet - 2016 - theses.hal.science
Quinze ans après la mise en place et l'accès élargi au traitement antirétroviral (TAR) dans
les pays du Sud, la suppression virale, objectif clé de son efficacité, n'est pas atteinte chez …
les pays du Sud, la suppression virale, objectif clé de son efficacité, n'est pas atteinte chez …