Vascular smooth muscle remodeling in conductive and resistance arteries in hypertension

IAM Brown, L Diederich, ME Good… - … , and vascular biology, 2018 - Am Heart Assoc
Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …

Heparan sulfate: biosynthesis, structure, and function

JP Li, M Kusche-Gullberg - International review of cell and molecular …, 2016 - Elsevier
Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …

Human genetic disorders and knockout mice deficient in glycosaminoglycan

S Mizumoto, S Yamada… - BioMed research …, 2014 - Wiley Online Library
Glycosaminoglycans (GAGs) are constructed through the stepwise addition of respective
monosaccharides by various glycosyltransferases and maturated by epimerases and …

Genetic Variance in Heparan Sulfation Is Associated With Salt Sensitivity

JJ Oppelaar, B Ferwerda, MA Romman… - …, 2024 - ahajournals.org
BACKGROUND: High heritability of salt sensitivity suggests an essential role for genetics in
the relationship between sodium intake and blood pressure (BP). The role of …

Cell-Specific Expression of Uptake Transporters A Potential Approach for Cardiovascular Drug Delivery Devices

HE Meyer zu Schwabedissen, R Begunk… - Molecular …, 2014 - ACS Publications
Enhanced proliferation of human coronary artery smooth muscle cells (HCASMCs) and
thereby formation of neointima is one of the factors contributing to failure of coronary stents …

Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1

N Adhikari, M Billaud, M Carlson, SP Lake… - Molecular and cellular …, 2014 - Springer
Heparan sulfate proteoglycans act as co-receptors for many chemokines and growth factors.
The sulfation pattern of the heparan sulfate chains is a critical regulatory step affecting the …