Hereunder, we highlight bacterial membrane anionic lipids as attractive targets in the design
of antibacterial drugs which can be effective against both Gram-positive and Gram-negative …

Although aminoglycosides have been used as antibacterials for decades, their use has
been hindered by their inherent toxicity and the resistance that has emerged to these …

Shortly after the discovery of the first antibiotics, bacterial resistance began to emerge. Many
mechanisms give rise to resistance; the most prevalent mechanism of resistance to the …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

Aminoglycosides are highly potent, broad-spectrum antibiotics that exert their bactericidal
therapeutic effect by selectively binding to the decoding aminoacyl site (A-site) of the …

Despite their inherent toxicity and the acquired bacterial resistance that continuously
threaten their long-term clinical use, aminoglycosides (AGs) still remain valuable …

Cationic amphiphiles derived from aminoglycosides (AGs) have been shown to exhibit
enhanced antimicrobial activity. Through the attachment of hydrophobic residues such as …

Despite their clinical importance, saving numerous human lifes, over-and mis-uses of
antibiotics have created a strong selective pressure on bacteria, which induces the …

Since the discovery of the first aminoglycoside (AG), streptomycin, in 1943, these broad-
spectrum antibiotics have been extensively used for the treatment of Gram-negative and …

Aminoglycosides (AGs) constitute a major family of potent and broad-spectrum antibiotics
disturbing protein synthesis through binding to the A site of 16S rRNA. Decades of …