Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-
containing molecules that can induce DNA damage and affect the DNA damage response …

The serine/threonine kinase CHK2 is a key component of the DNA damage response. In
human cells, following genotoxic stress, CHK2 is activated and phosphorylates> 20 proteins …

Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part
of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer …

Enormous strides have recently been made in our understanding of the biology and
pathobiology of mitochondria. Many diseases have been identified as caused by …

Objective: Our objective was to execute a prospective cohort study to determine
relationships between plasma mtDNA DAMP levels and the occurrence of systemic …

An explosion of new information about mitochondria reveals that their importance extends
well beyond their time-honored function as the “powerhouse of the cell.” In this Perspectives …

Background Arnica montana L. and Artemisia absinthium L.(Asteraceae) are medicinal
plants native to temperate regions of Europe, including Romania, traditionally used for …

Nitrogen mustards, widely used as chemotherapeutics, have limited safety and efficacy.
Mitochondria lack a functional nucleotide excision repair mechanism to repair DNA adducts …

PARPs play fundamental roles in multiple DNA damage recognition and repair pathways.
Persistent nuclear PARP activation causes cellular NAD+ depletion and exacerbates …

Reactive oxygen species (ROS), continuously generated as by-products of respiration, inflict
more damage on the mitochondrial (mt) than on the nuclear genome because of the …