Treatment-refractory giardiasis: challenges and solutions

M Lalle, K Hanevik - Infection and drug resistance, 2018 - Taylor & Francis
Giardia is the commonest parasitic diarrheal pathogen affecting humans and a frequent
cause of waterborne/foodborne parasitic diseases worldwide. Prevalence of giardiasis is …

Drug resistance in Giardia: Mechanisms and alternative treatments for Giardiasis

R Argüello-García, D Leitsch, T Skinner-Adams… - Advances in …, 2020 - Elsevier
The use of chemotherapeutic drugs is the main resource against clinical giardiasis due to
the lack of approved vaccines. Resistance of G. duodenalis to the most used drugs to treat …

The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

KO Alfarouk, AHH Bashir, AN Aljarbou… - Frontiers in …, 2019 - frontiersin.org
Helicobacter pylori (HP) is a facultative anaerobic bacterium. HP is a normal flora having
immuno-modulating properties. This bacterium is an example of a microorganism inducing …

Anti-Giardia Drug Discovery: Current Status and Gut Feelings

A Riches, CJS Hart, KR Trenholme… - Journal of medicinal …, 2020 - ACS Publications
Giardia parasites are ubiquitous protozoans of global importance that impact a wide range
of animals including humans. They are the most common enteric pathogen of cats and dogs …

Giardiasis: characteristics, pathogenesis and new insights about treatment

V Vivancos, I González-Alvarez… - Current topics in …, 2018 - ingentaconnect.com
Giardia intestinalis infection causes enterocytes damage and loss of brush border of the
epithelial cells of the intestine that leads to shortening of microvilli and altered epithelial …

Giardiasis in the post genomic era: treatment, drug resistance and novel therapeutic perspectives

M Lalle - Infectious Disorders-Drug Targets (Formerly Current …, 2010 - ingentaconnect.com
Giardia duodenalis (syn. G. lamblia, G. intestinalis) is a flagellated protozoan, member of the
order Diplomonadidae, that parasitizes the upper part of the small intestine of mammals …

Antimicrobial resistance of the enteric protozoon Giardia duodenalis – A narrative review

U Loderstädt, H Frickmann - European Journal of Microbiology and …, 2021 - akjournals.com
Introduction As therapy-refractory giardiasis is an emerging health issue, this review aimed
at summarizing mechanisms of reduced antimicrobial susceptibility in Giardia duodenalis …

Pyridyl Methylsulfinyl Benzimidazole Derivatives as Promising Agents against Giardia lamblia and Trichomonas vaginalis

B Hernández-Ochoa, V Martínez-Rosas… - Molecules, 2022 - mdpi.com
Protozoan parasites, such as Giardia lamblia and Trichomonas vaginalis, cause the most
prevalent infections in humans in developing countries and provoke significant morbidity …

Acid-suppressive therapy and risk of infections: pros and cons

L Fisher, A Fisher - Clinical drug investigation, 2017 - Springer
This narrative review summarises the benefits, risks and appropriate use of acid-
suppressing drugs (ASDs), proton pump inhibitors and histamine-2 receptor antagonists …

Recent advances in the development of triose phosphate isomerase inhibitors as antiprotozoal agents

LK Vázquez-Jiménez, A Moreno-Herrera… - Current Medicinal …, 2022 - ingentaconnect.com
Background: Parasitic diseases caused by protozoa, such as Chagas disease,
leishmaniasis, malaria, African trypanosomiasis, amoebiasis, trichomoniasis, and giardiasis …