Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …

Classically, platelets have been described as the cellular blood component that mediates
hemostasis and thrombosis. This important platelet function has received significant …

Extracellular vesicles (EVs) are small membrane‐bound vesicles released by cells under
various conditions. They are found in the extracellular milieu in all biological fluids. As the …

Background Mitochondria play a critical role in the production of cell energy and the
regulation of cell death. Therefore, mitochondria orchestrate numerous cell effector …

Nucleic acid autoantibodies, increase type I interferon (IFN-α) levels, and immune cell
hyperactivation are hallmarks of systemic lupus erythematosus (SLE). Notably, immune cell …

Kidney disease is a major global health concern, affecting millions of people. Nephrologists
have shown interest in platelets because of coagulation disorders caused by renal diseases …

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. PANoptosis
is a novel form of programmed cell death involved in various inflammatory diseases. This …

Sepsis and autoimmune diseases remain major causes of morbidity and mortality. The last
decade has seen a new appreciation of platelets in host defense, in both immunity and …

Objective Platelets are mediators of inflammation with immune effector cell properties and
have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). This …

Systemic lupus erythematosus (SLE) is an autoimmune disease leading to inflammatory
damage in multiple target organs, and lupus nephritis (LN) is one of the most life …