The global scale-up of antiretroviral (ARV) therapy (ART) has led to dramatic reductions in
HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential …

Highlights•Technological innovations enable the global roll-out of drug resistance
surveillance.•Next-generation sequencing provides an answer for simultaneous resistance …

HIV/AIDS is a global public health crisis that is yet to be contained. Effective management of
HIV drug resistance (HIVDR) supported by close resistance monitoring is essential in …

Human immunodeficiency virus (HIV) is a chronic infection that can be managed by
antiretroviral treatment (ART). However, periods of suboptimal viral suppression during …

Background HIV drug resistance (HIVDR) testing can assist clinicians in selecting
treatments. However, high complexity and cost of genotyping assays limit routine testing in …

ABSTRACT HIV drug resistance (HIVDR) is a barrier to sustained virologic suppression in
low-and middle-income countries (LMICs). Point mutation assays targeting priority drug …

Objectives: An increasing prevalence of HIV pretreatment drug resistance (PDR) has been
observed in Africa, which could decrease the effectiveness of antiretroviral therapy (ART) …

Introduction: pre-treatment drug resistance (PDR) can compromise the 3rd 95-95-95 global
target for viral load suppression. The high complexity and cost of genotyping assays limits …

The multiplex detection of point mutations plays an increasingly important role in clinical
diagnosis of genetic-based diseases. The present study reports a novel technology for the …

AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of “90-
90-90” to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 …