Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …

Cancer is the leading cause of death worldwide, and the number of cancer-related deaths is
expected to increase. Common types of cancer include skin, breast, lung, prostate, and …

Aims Doxorubicin, an antibiotic belonging to anthracycline family, has been used for
treatment of malignancies. Cardiotoxicity is the main adverse effect of doxorubicin. Apigenin …

The present study aimed to determine whether apelin-13 could attenuate cardiac fibrosis via
inhibiting the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway to inhibit …

Doxorubicin (DOX) is a potent chemotherapeutic agent that is used against various types of
human malignancies. However, the associated risk of cardiotoxicity has limited its clinical …

Cardiovascular disease created enormous health and economic burdens worldwide, which
is responsible for the highest mobility and mortality that results in nearly 6.2% of in‐hospital …

Noise-induced hearing loss (NIHL) is the second most common cause of acquired hearing
loss. Acoustic trauma can cause oxidative damage in the cochlear hair cells (HCs) through …

In-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) is 5–
6%. Consequently, it is necessary to develop fundamentally novel drugs capable of …

Activation of the apelin receptor, or APJ, by apelin is considered a therapeutic avenue for
cardiovascular disease, including heart failure. Recently, a novel endogenous ligand for …

Heart failure is one of the most significant public health problems faced by millions of
medical researchers worldwide. And pathological cardiac hypertrophy is considered one of …