What matters in aging is signaling for responsiveness

SC Park, YS Lee, KA Cho, SY Kim, YI Lee… - Pharmacology & …, 2023 - Elsevier
Biological responsiveness refers to the capacity of living organisms to adapt to changes in
both their internal and external environments through physiological and behavioral …

Molecular mechanisms of the anti-inflammatory effects of epigallocatechin 3-gallate (EGCG) in LPS-Activated BV-2 microglia cells

A Payne, E Taka, GM Adinew, KFA Soliman - Brain Sciences, 2023 - mdpi.com
Chronic neuroinflammation is associated with many neurodegenerative diseases, such as
Alzheimer's. Microglia are the brain's primary immune cells, and when activated, they …

[HTML][HTML] Senescence Rejuvenation through Reduction in Mitochondrial Reactive Oxygen Species Generation by Polygonum cuspidatum Extract: In Vitro Evidence

JH Yoon, YH Kim, EY Jeong, YH Lee, Y Byun, SS Shin… - Antioxidants, 2024 - mdpi.com
Oxidative stress caused by reactive oxygen species (ROS) is one of the major causes of
senescence. Strategies to reduce ROS are known to be important factors in reversing …

Therapy-induced senescence in breast cancer: an overview

SN Chembukavu, AJ Lindsay - Exploration of Targeted Anti …, 2024 - pmc.ncbi.nlm.nih.gov
Outcomes for women with breast cancer have improved dramatically in recent decades.
However, many patients present with intrinsic drug resistance and others are initially …

[HTML][HTML] Synergistic ROS Reduction Through the Co-Inhibition of BRAF and p38 MAPK Ameliorates Senescence

MU Kuk, D Kim, YH Lee, JH Yoon, JH Park… - …, 2024 - pmc.ncbi.nlm.nih.gov
Reactive oxygen species (ROS)-mediated damage to macromolecules and cellular
organelles is one of the major causes of senescence. Therapeutic strategies that lower ROS …

[HTML][HTML] Antioxidant and anti-ageing effects of oleuropein aglycone in canine skeletal muscle cells

G Polacchini, A Venerando, M Colitti - Tissue and Cell, 2024 - Elsevier
Reactive oxygen species (ROS) are normally produced in skeletal muscle. However, an
imbalance in their regulatory systems can lead to their accumulation and ultimately to …

Investigation of Therapy-Induced Senescent Cancer Cell Phenotypes with Mass Spectrometry and Non-Linear Optical Microscopy

S Ghislanzoni - 2024 - oro.open.ac.uk
In response to chemotherapy and radiotherapy, a subset of resistant cancer cells avoids cell
death by entering a stable state known as senescence, characterized by prolonged cell …