Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Growing evidence indicates that oxidative and endoplasmic reticular stress, which trigger
changes in ion channels and inflammatory pathways that may undermine cellular …

Receptor activator of NF-κB (RANK) expression is increased in podocytes of patients with
diabetic nephropathy. However, the relevance of RANK to diabetic nephropathy …

Phosphatase and tensin homolog (PTEN) is a potent tumor suppressor gene that
antagonizes the proto-oncogenic phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) …

Abstract Phosphatase and Tensin Homolog on chromosome Ten (PTEN) has emerged as a
key protein that governs the response to kidney injury. Notably, renal adaptive repair is …

Abstract Histone deacetylase 6 (HDAC6) is the specific subtype of HDACs which
preferentially located in the cytoplasm, and is crucial in insulin signalling. However, the role …

With the increasing prevalence of obesity in adults worldwide, the incidence of obesity-
related glomerulopathy (ORG) has increased yearly, becoming one of the leading causes of …

Chronic kidney disease (CKD) is the main cause of end-stage renal disease worldwide
arising as a frequent complication of diabetes, obesity, and hypertension. Current …

Background The aberrant expression of long noncoding RNAs (lncRNAs) has been
associated with diabetic nephropathy (DN), a major complication of diabetes mellitus (DM) …

Although diabetic glomerulopathy is a characteristic of diabetic kidney disease (DKD),
manifesting as a thickened glomerular basement membrane, mesangial expansion with …