Topoisomerases as anticancer targets
JL Delgado, CM Hsieh, NL Chan… - Biochemical Journal, 2018 - portlandpress.com
Many cancer type-specific anticancer agents have been developed and significant
advances have been made toward precision medicine in cancer treatment. However …
advances have been made toward precision medicine in cancer treatment. However …
[HTML][HTML] Recent developments in topoisomerase-targeted cancer chemotherapy
KE Hevener, TA Verstak, KE Lutat, DL Riggsbee… - … pharmaceutica sinica B, 2018 - Elsevier
The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously
in all domains of life. The various topoisomerase enzymes perform a wide range of functions …
in all domains of life. The various topoisomerase enzymes perform a wide range of functions …
All tangled up: how cells direct, manage and exploit topoisomerase function
SM Vos, EM Tretter, BH Schmidt… - Nature reviews Molecular …, 2011 - nature.com
Topoisomerases are complex molecular machines that modulate DNA topology to maintain
chromosome superstructure and integrity. Although capable of stand-alone activity in vitro …
chromosome superstructure and integrity. Although capable of stand-alone activity in vitro …
DNA topoisomerases: structure, function, and mechanism
JJ Champoux - Annual review of biochemistry, 2001 - annualreviews.org
▪ Abstract DNA topoisomerases solve the topological problems associated with DNA
replication, transcription, recombination, and chromatin remodeling by introducing …
replication, transcription, recombination, and chromatin remodeling by introducing …
Cellular roles of DNA topoisomerases: a molecular perspective
JC Wang - Nature reviews Molecular cell biology, 2002 - nature.com
DNA topoisomerases are the magicians of the DNA world—by allowing DNA strands or
double helices to pass through each other, they can solve all of the topological problems of …
double helices to pass through each other, they can solve all of the topological problems of …
New mechanistic and functional insights into DNA topoisomerases
SH Chen, NL Chan, T Hsieh - Annual review of biochemistry, 2013 - annualreviews.org
DNA topoisomerases are nature's tools for resolving the unique problems of DNA
entanglement that occur owing to unwinding and rewinding of the DNA helix during …
entanglement that occur owing to unwinding and rewinding of the DNA helix during …
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA
Topoisomerases I promote the relaxation of DNA superhelical tension by introducing a
transient single-stranded break in duplex DNA and are vital for the processes of replication …
transient single-stranded break in duplex DNA and are vital for the processes of replication …
A model for the mechanism of human topoisomerase I
The three-dimensional structure of a 70-kilodalton amino terminally truncated form of human
topoisomerase I in complex with a 22–base pair duplex oligonucleotide, determined to a …
topoisomerase I in complex with a 22–base pair duplex oligonucleotide, determined to a …
Structure and mechanism of DNA topoisomerase II
JM Berger, SJ Gamblin, SC Harrison, JC Wang - Nature, 1996 - nature.com
The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-
shaped dimeric protein with a large central hole. It provides a molecular model of the …
shaped dimeric protein with a large central hole. It provides a molecular model of the …
A transmembrane helix dimer: structure and implications
The three-dimensional structure of the dimeric transmembrane domain of glycophorin A
(GpA) was determined by solution nuclear magnetic resonance spectroscopy of a 40 …
(GpA) was determined by solution nuclear magnetic resonance spectroscopy of a 40 …