Upon entering a presynaptic terminal, an action potential opens Ca2+ channels, and
transiently increases the local Ca2+ concentration at the presynaptic active zone. Ca2+ then …

The yeast cell wall is a highly dynamic structure that is responsible for protecting the cell
from rapid changes in external osmotic potential. The wall is also critical for cell expansion …

Background: Human C-reactive protein (CRP) is the classical acute phase reactant, the
circulating concentration of which rises rapidly and extensively in a cytokine-mediated …

Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in
a multitude of cellular processes, ranging from control of fundamental cell autonomous …

In all synapses, Ca2+ triggers neurotransmitter release to initiate signal transmission. Ca2+
presumably acts by activating synaptic Ca2+ sensors, but the nature of these sensors …

The slow afterhyperpolarization that follows an action potential is generated by the activation
of small-conductance calcium-activated potassium channels (SK channels). The slow …

The EF-hand motif is the most common calcium-binding motif found in proteins. Several high-
resolution structures containing different metal ions bound to EF-hand sites have given new …

Phosphoinositide-specific phospholipase C (PLC) subtypes β, γ, and δ comprise a related
group of multidomain phosphodiesterases that cleave the polar head groups from inositol …

The C2 domain is a Ca2+‐binding motif of approximately 130 residues in length originally
identified in the Ca2+‐dependent isoforms of protein kinase C. Single and multiple copies of …

A vast amount of protein sequence data accumulated over recent years has revealed that
protein modules are widespread in nature. Many intracellular and extracellular proteins …