For almost four decades, my work has focused on one challenge: improving the delivery and
efficacy of anticancer therapeutics. Working on the hypothesis that the abnormal tumor …

Light is used extensively in biological and medical research for optogenetic
neuromodulation, fluorescence imaging, photoactivatable gene editing and light-based …

Approximately 2% of colorectal cancer is linked to pre-existing inflammation known as colitis-
associated cancer, but most develops in patients without underlying inflammatory bowel …

Despite having an abundant number of vessels, tumours are usually hypoxic and nutrient-
deprived because their vessels malfunction. Such abnormal milieu can fuel disease …

New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …

Microcirculation (2010) 17, 206–225. doi: 10.1111/j. 1549‐8719.2010. 00029. x Abstract
Intravital imaging techniques have provided unprecedented insight into tumor …

Advances in photonics have stimulated significant progress in medicine, with many
techniques now in routine clinical use. However, the finite depth of light penetration in tissue …

Current anti-VEGF therapies for colorectal cancer (CRC) provide limited survival benefit, as
tumors rapidly develop resistance to these agents. Here, we have uncovered an …

Rationale: High-resolution imaging of the heart in vivo is challenging owing to the difficulty in
accessing the heart and the tissue motion caused by the heartbeat. Objective: Here, we …

Large-scale cancer genomics, proteomics and RNA-sequencing efforts are currently
mapping in fine detail the genetic and biochemical alterations that occur in cancer. However …