Interfering RNA molecules
K Giese, J Kaufmann, A Klippel-Giese - US Patent 7,452,987, 2008 - Google Patents
The present invention is related to a ribonucleic acid com prising a double stranded
structure whereby the double Stranded structure comprises a first strand and a second …
structure whereby the double Stranded structure comprises a first strand and a second …
Modified polynucleotides for reducing off-target effects in RNA interference
D Leake, A Reynolds, A Khvorova, W Marshall… - US Patent …, 2009 - Google Patents
Methods and compositions for performing RNA interference with decreased off-target effects
are provided The methods and compositions permit effective and efficient applications of …
are provided The methods and compositions permit effective and efficient applications of …
Oligoribonucleotides and ribonucleases for cleaving RNA
ST Crooke - US Patent 7,695,902, 2010 - Google Patents
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
D Brown, L Ford, R Jarvis - US Patent App. 10/298,480, 2004 - Google Patents
The present invention concerns methods and compositions involving the production or
generation of siRNA mixtures or pools capable of triggering RNA-mediated interference …
generation of siRNA mixtures or pools capable of triggering RNA-mediated interference …
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
C Allerson, B Bhat, AB Eldrup, M Manoharan… - US Patent …, 2013 - Google Patents
2004-05-18 Assigned to ISIS PHARMACEUTICALS, INC. reassignment ISIS
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Positionally modified siRNA constructs
B Bhat, EE Swayze, TP Prakash, C Allerson… - US Patent …, 2013 - Google Patents
The present invention provides oligomeric compounds hav ing su? icient complementarity to
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …
Modulators of pharmacological agents
BA Sullenger, CP Rusconi - US Patent 7,300,922, 2007 - Google Patents
The biological activity of nucleic acid ligand is regulated (ie enhanced or inhibited) in vivo to
produce a desired biological e?'ect. This is accomplished through the admin istration of a …
produce a desired biological e?'ect. This is accomplished through the admin istration of a …
Compounds and methods for modulating expression of sglt2
S Bhanot, RS Geary, R McKay, BP Monia… - US Patent App. 12 …, 2009 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
40134111&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
40134111&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Interfering RNA molecules
K Giese, J Kaufmann, A Klippel-Giese - US Patent 9,222,092, 2015 - Google Patents
The present invention is related to a ribonucleic acid comprising a double stranded structure
whereby the double-stranded structure comprises a first strand and a second strand …
whereby the double-stranded structure comprises a first strand and a second strand …
Sugar modified oligonucleotides
PD Cook - US Patent 6,399,754, 2002 - Google Patents
FOREIGN PATENT DOCUMENTS Compositions and methods are provided for the treatment
CA 2017369 11/1990 and diagnosis of diseases amenable to modulation of the DE …
CA 2017369 11/1990 and diagnosis of diseases amenable to modulation of the DE …