Many thousands of lipid species exist and their metabolism is interwoven via numerous
pathways and networks. These networks can also change in response to cellular …

The central functions fulfilled by mitochondria as both energy generators essential for tissue
homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight …

The focus of the present study was to define the human plasma lipidome and to establish
novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid …

Nonalcoholic fatty liver disease (NAFLD) comprises fat-accumulating conditions within
hepatocytes that can cause severe liver damage and metabolic comorbidities. Studies …

Mitochondrial diseases involve the respiratory chain, which is under the dual control of
nuclear and mitochondrial DNA (mtDNA). The complexity of mitochondrial genetics provides …

Since it has been recognized that mitochondria are crucial not only for energy metabolism
but also for other cellular functions, there has been a growing interest in cardiolipin, the …

The recent discovery of interconnections between the endoplasmic reticulum (ER)
membrane and those of almost all the cell compartments is providing novel perspectives for …

Cardiolipin (CL) is a structurally unique dimeric phospholipid localized in the inner
mitochondrial membrane where it is required for optimal mitochondrial function. In addition …

Among mitochondrial lipids, cardiolipin occupies a unique place. It is the only phospholipid
that is specific to mitochondria and although it is merely a minor component, accounting for …

Lipidomics aims to quantitatively define lipid classes, including their molecular species, in
biological systems. Lipidomics has experienced rapid progress, mainly because of …