Reactive oxygen species (ROS) mediate lipid peroxidation and produce 4-hydroxynonenal
and other related products, which play an important role in the process of cell death …

Colorectal cancer (CRC) is a predominant malignancy worldwide, being the fourth most
common cause of mortality and morbidity. The CRC incidence in adolescents, young adults …

Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer-related death. Most cases of CRC are detected in Western countries, with its …

Colorectal cancer (CRC), as a prominent cause of cancer-related deaths, has historically
been notable worldwide and many attempts have been made to raise the overall survival of …

Autophagy is a self-eating process of using lysosomes to degrade macromolecular
substances (eg, proteins and organelles) that are damaged, degenerated, or aging. Lipid …

Evidence indicates that diet, nutrition, lifestyle, the environment, the microbiome, and other
exogenous factors have pathogenic roles and also influence the genome, epigenome …

Development of novel and effective therapeutics for treating various cancers is probably the
most congested and challenging enterprise of pharmaceutical companies. Diverse drugs …

Background & Aims Incidence of colorectal cancer (CRC) in younger adults is increasing in
many countries. Given the established association of body mass index (BMI) with CRC risk …

Objective Evidence suggests that CD274 (programmed death-ligand 1, B7-H1) immune
checkpoint ligand repress antitumour immunity through its interaction with the PDCD1 …

Obesity is associated with an increased risk of estrogen receptor-positive breast cancer in
postmenopausal women and a worse prognosis for all major breast cancer subtypes …