[HTML][HTML] Microplate selection and recommended practices in high-throughput screening and quantitative biology
DS Auld, PA Coassin, NP Coussens… - Assay Guidance …, 2020 - ncbi.nlm.nih.gov
High-throughput screening (HTS) can efficiently assay multiple discrete biological reactions
using multi-well microplates. The choice of microplate is a crucial yet often overlooked …
using multi-well microplates. The choice of microplate is a crucial yet often overlooked …
Detecting and overcoming systematic bias in high-throughput screening technologies: a comprehensive review of practical issues and methodological solutions
I Caraus, AA Alsuwailem, R Nadon… - Briefings in …, 2015 - academic.oup.com
Significant efforts have been made recently to improve data throughput and data quality in
screening technologies related to drug design. The modern pharmaceutical industry relies …
screening technologies related to drug design. The modern pharmaceutical industry relies …
Assay establishment and validation of a high-throughput screening platform for three-dimensional patient-derived colon cancer organoid cultures
K Boehnke, PW Iversen… - Journal of …, 2016 - journals.sagepub.com
The application of patient-derived three-dimensional culture systems as disease-specific
drug sensitivity models has enormous potential to connect compound screening and clinical …
drug sensitivity models has enormous potential to connect compound screening and clinical …
[HTML][HTML] A pair of new statistical parameters for quality control in RNA interference high-throughput screening assays
XD Zhang - Genomics, 2007 - Elsevier
RNA interference (RNAi) high-throughput screening (HTS) enables massive parallel gene
silencing and is increasingly being used to reveal novel connections between genes and …
silencing and is increasingly being used to reveal novel connections between genes and …
Chemical genetics reveals a complex functional ground state of neural stem cells
The identification of self-renewing and multipotent neural stem cells (NSCs) in the
mammalian brain holds promise for the treatment of neurological diseases and has yielded …
mammalian brain holds promise for the treatment of neurological diseases and has yielded …
Developing and validating predictive decision tree models from mining chemical structural fingerprints and high–throughput screening data in PubChem
L Han, Y Wang, SH Bryant - BMC bioinformatics, 2008 - Springer
Background Recent advances in high-throughput screening (HTS) techniques and readily
available compound libraries generated using combinatorial chemistry or derived from …
available compound libraries generated using combinatorial chemistry or derived from …
Informatics challenges of high-throughput microscopy
In this article, we discussed the emerging informatics issues of high-throughput screening
(HTS) using automated fluorescence microscopy technology, otherwise known as high …
(HTS) using automated fluorescence microscopy technology, otherwise known as high …
The use of strictly standardized mean difference for hit selection in primary RNA interference high-throughput screening experiments
RNA interference (RNAi) high-throughput screening (HTS) has been hailed as the 2nd
genomics wave following the 1st genomics wave of gene expression microarrays and single …
genomics wave following the 1st genomics wave of gene expression microarrays and single …
Robust statistical methods for hit selection in RNA interference high-throughput screening experiments
X Douglas Zhang, XC Yang, N Chung, A Gates… - …, 2006 - Taylor & Francis
RNA interference (RNAi) high-throughput screening (HTS) experiments carried out using
large (> 5000 short interfering [si] RNA) libraries generate a huge amount of data. In order to …
large (> 5000 short interfering [si] RNA) libraries generate a huge amount of data. In order to …
An efficient method for the detection and elimination of systematic error in high-throughput screening
V Makarenkov, P Zentilli, D Kevorkov, A Gagarin… - …, 2007 - academic.oup.com
Motivation: High-throughput screening (HTS) is an early-stage process in drug discovery
which allows thousands of chemical compounds to be tested in a single study. We report a …
which allows thousands of chemical compounds to be tested in a single study. We report a …