Since our previous review, 1 there has been a tremendous development in the field of
carbazole alkaloids. New synthetic methodologies have been developed, existing …

Covering: up to May 2006. This Highlight provides an overview of the molecular logic
employed in the formation and elaboration of pyrroles during natural product biosyntheses …

Covering: up to June 2006 The indolocarbazole family of natural products, including the
biosynthetically related bisindolylmaleimides, is reviewed (with 316 references cited). The …

This series is world-renowned as the leading compilation of current reviews of this vast field.
Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology …

Staurosporine was discovered at the Kitasato Institute in 1977 while screening for microbial
alkaloids using chemical detection methods. It was during the same era that protein kinase …

The purple chromobacterial pigment violacein arises by enzymatic oxidation and coupling of
two molecules of l-tryptophan to give a rearranged pyrrolidone-containing scaffold in the …

The biosynthetic pathways for violacein and for indolocarbazoles (rebeccamycin,
staurosporine) include a decarboxylative fusion of two tryptophan units. However, in the …

Methanotrophs are potent natural producers of several bioactive secondary metabolites
(SMs) including isoprenoids, polymers, peptides, and vitamins. Cryptic biosynthetic gene …

The antitumor fungal metabolite terrequinone A, identified in extracts of Aspergillus sp., is
biosynthesized by the five-gene cluster tdiA–tdiE. In this work, we have overproduced all five …

In the biosynthesis of the antitumor indolocarbazoles rebeccamycin and staurosporine by
streptomycetes, assembly of the aglycones involves a complex set of oxidative …