Cancer is one of the most common causes of death globally. Despite extensive research
and considerable advances in cancer therapy, the fundamentals of the disease remain …

Altered expression and function of the transcription factor cyclic AMP response-binding
protein (CREB) has been identified to play an important role in cancer and is associated with …

Acute myeloid leukemia (AML) represents a clonal disease of hematopoietic progenitors
characterized by acquired heterogenous genetic changes that alter normal mechanisms of …

MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast
to the oncogenic role of miR-22 reported in myelodysplastic syndrome (MDS) and breast …

Simple Summary Only 5% of all drug-related targets currently move from preclinical to
clinical in cancer, and just some of them achieve patient's bedside. Among others, intratumor …

The cyclic AMP response element binding (CREB) protein has pleiotropic activities in
physiologic processes. Due to its central position downstream of many growth signaling …

Myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) are aggressive
myeloid malignancies recognized as a distinct category owing to their unique combination of …

Abstract miRNAs and DNA methylation are both critical regulators of gene expression.
Aberration in miRNA expression or DNA methylation is a causal factor for numerous …

Acute myeloid leukemia (AML) is a hematologic malignancy that is the most common type of
acute leukemia diagnosed in adults and the second most common type in children. The …

There is an imbalance in asthma between classically activated macrophages (M1 cells) and
alternatively activated macrophages (M2 cells) in favor of the latter. MicroRNAs (miRNAs) …