Approximately 50% of epithelial ovarian cancers (EOC) exhibit defective DNA repair via
homologous recombination (HR) due to genetic and epigenetic alterations of HR pathway …

Poly (ADP-ribose) polymerase (PARP) inhibitors have shown promising activity in epithelial
ovarian cancers, especially relapsed platinum-sensitive high-grade serous disease …

Small-molecule inhibitors of PARP are thought to mediate their antitumor effects as catalytic
inhibitors that block repair of DNA single-strand breaks (SSB). However, the mechanism of …

Abstract Poly (ADP-ribosyl) ation (PARylation) is a post-translational modification of proteins
catalysed by Poly (ADP-ribose) polymerases (PARP). A wealth of recent advances in the …

Among DNA damages, double-strand breaks (DSBs) are one of the most harmful lesions to
a cell. Failure in DSB repair could lead to genomic instability and cancer. Homologous …

Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP-ribosylating enzyme essential for
initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus …

DNA damage response (DDR) deficiencies result in genome instability, which is one of the
hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various …

DNA double-strand breaks (DSBs) are fatal DNA lesions and activate a rapid DNA damage
response. However, the earliest stage of DSB sensing remains elusive. Here, we report that …

Acute myeloid leukemia (AML) is mostly driven by oncogenic transcription factors, which
have been classically viewed as intractable targets using small-molecule inhibitor …

Adenosine diphosphate (ADP)-ribosylation is an important posttranslational modification
catalyzed by a variety of enzymes, including poly (ADP ribose) polymerases (PARPs), which …