Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

Plasma membrane localized anoctamin 1, 2 and 6 (TMEM16A, B, F) have been examined in
great detail with respect to structure and function, but much less is known about the other …

Abstract Anoctamin 3 (ANO3) belongs to a family of transmembrane proteins that form
phospholipid scramblases and ion channels. A large number of ANO3 variants were …

Abstract Calcium (Ca2+)-activated ion channels and lipid scramblases in the
transmembrane protein 16 (TMEM16) family are structurally related to mechanosensitive ion …

Neuropathic pain is a characteristic feature of small fiber neuropathy (SFN), which in 18% of
the cases is caused by genetic variants in voltage-gated sodium ion channels. In this study …

Abstract The Illuminating the Druggable Genome (IDG) consortium is a National Institutes of
Health (NIH) Common Fund program designed to enhance our knowledge of under‐studied …

TMEM16 proteins, which function as Ca2+-activated Cl− channels are involved in regulating
a wide variety of cellular pathways and functions. The modulators of Cl− channels can be …

Febrile seizures (FSs) are the most common pediatric neurological disorder, affecting
approximately 5% of children aged 6 months to 5 years. While most FSs are self-limiting and …

TMEM16 proteins, also known as anoctamins, are a family of ten membrane proteins with
various tissue expression and subcellular localization. TMEM16A (anoctamin 1) is a plasma …

Plasma membrane localized anoctamin 1, 2 and 6 (TMEM16A, B, F) have been examined in
great detail with respect to structure and function, but much less is known about the other …