Congenital obstructive nephropathy accounts for the greatest fraction of chronic kidney
disease in children. Genetic and nongenetic factors responsible for the lesions are largely …

Reactive oxygen species (ROS) play a key role in the pathophysiological processes of a
wide range of renal diseases. Thus, antioxidants are expected to decrease the vulnerability …

Ruxolitinib is a selective inhibitor of Jak1/2. Downstream signaling pathways of Jak, such as
Stat3 and Akt/mTOR, are overactivated and contribute to renal interstitial fibrosis. Therefore …

Acute kidney injury (AKI) is a common clinical syndrome that is related to high morbidity and
mortality. Oxidative stress, including the production of reactive oxygen species (ROS) …

Obstructive nephropathy is a major cause of renal failure, particularly in infants and children.
Cellular and molecular mechanisms responsible for the progression of the tubular atrophy …

Over the last decade, oxidative stress has been implicated in the pathogenesis of a wide
variety of seemingly unrelated renal diseases. Epidemiological studies have documented an …

Angiotensin II plays a pivotal role in the progression of renal diseases, including obstructive
nephropathy. Increasing levels of angiotensin II in obstructive nephropathy upregulate the …

Unilateral ureteric obstruction (UUO) is one of the most commonly applied rodent models to
study the pathophysiology of renal fibrosis. This model reflects important aspects of …

Purpose: We investigated the possible mechanism of increased free radicals, the role of
antioxidant enzymes and their correlation with renal tubular damage in the kidney after …

The current work explored the influences of nifuroxazide, an in vivo inhibitor of signal
transducer and activator of transcription-3 (STAT-3) activation, on tubulointerstitial fibrosis in …